TP53 and legionellosis: Furthermore, the enriched KEGG pathways of DEGs at 4 h included the HIF-1 signaling pathway, legionellosis, transcriptional misregulation, central carbon metabolism, circadian rhythm, fructose and mannose metabolism and autophagy (Figure 3E), and those at 8 h included the HIF-1 signaling pathway, p53 signaling pathway, cellular senescence, biosynthesis of amino acids, legionellosis, calcium signaling pathway, central carbon metabolism and cell cycle (Figure 3F).