ZAP-70 and CD38 are reported as reliable predictors of disease progression (Damle et al., 1999; Crespo et al., 2003) whereas LPL, ITGA4, MCL1 have been recently proposed as prognostic of negative outcome for patients with CLL (Browning et al., 2007; Van Bockstaele et al., 2007; Pepper et al., 2008; Mansouri et al., 2010). This evidence concerns the gene LPL and B-cell chronic lymphocytic leukemia.