More in detail, PBMCs from 12 CLL patients were transfected with siRNA for ZNF224 or control scrambled siRNA and by RT-qPCR we showed the reduction of p50 and p65, components of the NF-κB transcription factor family, CCND1, BCL2 and BAX, targets of NF-κB involved in proliferation/survival signaling (Figure 6A). Here, BCL2 is linked to B-cell chronic lymphocytic leukemia.