Instead, absence of correlation was found between ZNF224 and TNFAIP3, the gene encoding protein A20, whose genetic alterations are not associated with the constitutive activation of NF-κB pathway in CLL (Frenzel et al., 2011; Philipp et al., 2011). The gene discussed is NFKB1; the disease is B-cell chronic lymphocytic leukemia.