Moreover, the strong relationship between ZNF224, BCL2 and BAX in the analyzed datasets, and the downmodulation of BCL2 and BAX RNA following ZNF224 knockdown support the notion that overexpression of both anti- and pro-apoptotic proteins of the BCL-2 family occurs in CLL, contributing to dysregulated apoptosis (Kitada et al., 1998; Aviram et al., 2000; Helaly et al., 2021) and indicates the involvement of ZNF224 in the regulation of their expression. Here, ZNF224 is linked to B-cell chronic lymphocytic leukemia.