The mRNAs of TP53, CAD, ACLY, IMPDH2, and YARS were found to be highly expressed in tumor cells among these genes and down-regulated by Chidamide treatment; the mRNAs of THBS1 and CXCL8 were highly expressed in tumor cells, and the expression was higher after treatment with Chidamide. This evidence concerns the gene IMPDH2 and neoplasm.