Wild type TP53 plays an important role in maintaining normal cell growth and inhibiting malignant proliferation, while in contrast, mutant TP53 gene affects normal cell division and promotes abnormal proliferation of tumor cells, eventually leading to carcinogenesis, and human malignant tumors are most commonly of the mutant type (Bourdon, 2007; Hong et al., 2014; Stein et al., 2019). This evidence concerns the gene TP53 and neoplasm.