IL10 and Sepsis: Meanwhile, Breg cells can also negatively regulate the immune responses, mainly by producing anti-inflammatory factors such as IL-10 and IL-35 to induce endotoxin tolerance or immunosuppression, inhibit innate immune responses and promote Treg responses in sepsis (Barbeiro et al., 2011; Tao et al., 2019; Dasgupta et al., 2020).