Adoptive transfer of B1a cells into septic mice markedly attenuated systemic inflammation and organ damage, and ultimately improved survival, in which IL-10 produced from B1a cells plays a key protective role because the mice treated with IL-10-deficient B1a cells were not protected against sepsis (Aziz et al., 2017; Aziz et al., 2018). Here, IL10 is linked to Sepsis.