Taken together, it can be concluded that IRA B cells may lead to diametrically opposite outcomes through producing different proportions of dominant cytokines in sepsis under certain conditions, and a fine-tuned balance diminishing IL-3 production while retaining GM-CSF secretion in IRA B cells is essential for the proper immune response against pathogens and the prevention of excessive damage during sepsis. This evidence concerns the gene CSF2 and Sepsis.