CD5 and Sepsis: Animal experiments have shown that the adoptive transfer of B1a cells or CD5+CD1dhi Breg cells can effectively reduce the inflammatory response, and prevent organ damage and severe endotoxic shock in mice with sepsis, suggesting that supplementation of specific B-cell subsets by adoptive immunotherapy could reverse the damage of B-cell reduction (Aziz et al., 2017; Aziz et al., 2018).