IL6 and Sepsis: In a mouse model of sepsis induced by intravenous injection of LPS or Escherichia coli (E.coli), MZ B cells could produce large amounts of inflammatory cytokines and chemokines via Fcα/μR-coupled Toll-like receptor four pathways, such as IL-6, and exacerbate systemic inflammatory responses and endotoxic shock in mice (Honda et al., 2016).