Moreover, the reports have revealed that SAA has a protective effect on diabetic complications in multiple rodent models, such as inhibiting hepatic fibrosis in HFD-fed and STZ-induced type 2 diabetic rats (Qiang et al., 2014), attenuating kidney injury and inflammation in 5/6 nephrectomized rats (Zhang et al., 2018), ameliorating early-stage atherosclerosis development via NLRP3 inflammasome in Zucker diabetic fatty rats (Zhang et al., 2018), and improving diabetic peripheral neuropathy in KK-Ay mice (Xu et al., 2020a). The gene discussed is NLRP3; the disease is atherosclerosis.