Recently, Marcus Conrad and José Pedro Friedmann Angeli’s team used a clonal expression strategy to screen for genes that can inhibit ferroptosis caused by loss of GPX4 in human cancer cells and found that flavoprotein apoptosis-inducing factor mitochondria-related 2 (AIFM2) is an anti-ferroptosis gene and renamed AIFM2 to ferroptosis suppressor protein 1 (FSP1). The gene discussed is AIFM2; the disease is cancer.