GPX4 and Stroke: It has been established that the levels of intracellular lipid peroxides and Fe2+ are increased during stroke, and ferroptosis inhibitors can upregulate the levels of GSH, GPX4 or system Xc− to alleviate brain damage, indicating that ferroptosis affects the progression of stroke (Magtanong and Dixon, 2018; Zhang et al., 2021b).