In addition, ischemia and hypoxia can induce the expression of VEGF (Ramakrishnan et al., 2014), which can promote the proliferation of VECs and participate in angiogenesis, thereby suppressing ischemic stroke and playing a neuroprotective role (Lopes-Bezerra and Filler, 2003; Zhou et al., 2020). This evidence concerns the gene VEGFA and ischemic stroke.