GPX4 and neoplasm: For example, HSPB1 can inhibit ferroptosis by reducing iron uptake (Sun et al., 2015); HSPA5 binds to and stabilizes GPX4, thereby indirectly avoiding the damage of lipid peroxidation in ferroptosis (Zhu et al., 2017); however, the HSP9 inhibitor CDDO can inhibit ferroptosis in tumor cells, suggesting that HSP90 may play a different role in ferroptosis (Qin et al., 2015).