IL6 and ischemic stroke: During ischemic stroke, the expression of interleukin-6 (IL-6) in cells increases hepcidin through the JAK/STAT3 pathway (Cojocaru et al., 2009), which causes FPN1 degradation, resulting in reduced iron release and thus intensified iron accumulation in cells (Cojocaru et al., 2009; Zhou et al., 2017).