EGFR and non-small cell lung carcinoma: In this study, we provided comprehensive evidence for the targeted response of diverse EGFR TKIs among heterogeneous ex20ins EGFR mutants to diverse EGFR TKIs in a real-world NSCLC cohort, along with structural insights into the binding modes and binding activities of the A763_Y764insFQEA and D770delinsGY variants in particular.