EGFR and non-small cell lung carcinoma: NSCLC cells expressing the D770_N771insSVD and V769_D770insASV mutants are resistant to both 1st-gen (IC50, 3479.3-5179.7 nM) and 2nd-gen (IC50, 54.1-85.9 nM) EGFR TKIs as opposed to those expressing the A763_Y764insFQEA variant (IC50, 21.7-33.3 nM to 1st-gen EGFR TKIs; 0.002–0.013 nM to 2nd-gen EGFR TKIs) or the wild-type EGFR (IC50, 1127-1333.1 nM to 1st-gen EGFR TKIs; 7.3-39 nM to 2nd-gen EGFR TKIs) (Lee et al., 2019).