Another 2018 systematic review and meta-analysis investigating 40 studies examining the role of lnRNAs in the clinicopathological features, diagnosis and prognosis of gliomas revealed that urothelial carcinoma associated 1 (UCA1) expression was positively associated with tumor size and WHO tumor grade, and that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) expression could predict poor OS in patients with glioma (86). This evidence concerns the gene MALAT1 and central nervous system cancer.