For instance, enhancer of zeste homolog 2 (EZH2), a histone methyltransferase involved in the upregulation of c-MYC (40), was shown to be highly involved the tumorigenesis of GBM and decreased the survival rates (41), therefore representing an important prognostic factor related to the grade of the glioma (42). Here, PRDM9 is linked to central nervous system cancer.