It was discovered that liver cancer tissues had lower levels of ANGPTL6, CFP, CLEC1B, CLEC4G, CLEC4M, COLEC10, CRHBP, CXCL12, DNASE1L3, FCN2, FCN3, GSTZ1, LCAT, NAT2, OIT3, RSPO3, VIPR1, STAB2, ECM1, and GPR128 expression compared to normal liver cells. The gene discussed is RSPO3; the disease is liver cancer.