However, cell adaptive response depends on stiffness, time and the genetic background of the cell line, as previously suggested in the literature (López-Carrasco et al., 2020; Monferrer, Sanegre, et al., 2020), so further genetic and drug-testing studies on long-cultured models, using various MYCN amplified and/or ALK mutated NB cell lines, should be performed to confirm which model better recapitulates high-risk NB behavior. Here, MYCN is linked to neuroblastoma.