MYCN and neuroblastoma: Our previous results with a clinical cohort and preclinical models (orthotopic xenograft VN knock-out (KO) mice and 3D bioprinted hydrogels with different stiffness) have also established that the interaction of VN, its ligands (e.g., αv integrins), and genomic intratumor heterogeneity in MYCN-amplified NB cell line are related to increased ECM stiffness (Burgos-Panadero, Noguera, et al., 2019; López-Carrasco et al., 2020; Monferrer, Martín-Vañó, et al., 2020; Monferrer, Sanegre, et al., 2020; Vicente-Munuera et al., 2020).