CAF (cancer-associated fibroblast)-derived exosomal miR-196a confers cisplatin resistance in HNSCC cells by targeting ING5 (Qin et al., 2019), and miR-193a-3p induces the chemoresistance of breast cancer cells by targeting ING5, in line with the effects of ING5 silencing (Li et al., 2015). This evidence concerns the gene ING5 and cancer.