Although a high ING5 expression was observed in gastric, breast, and colorectal cancers (Xing et al., 2011; Zhao et al., 2015; Wang et al., 2021; Zheng et al., 2022), ING5 was found to be expressed in osteosarcoma, prostate cancer, ovarian cancer, HCC, lung cancer, esophageal cancer, and thyroid cancer at a low level (Qi and Zhang, 2014; Cao et al., 2015; Zhang et al., 2015; Cui et al., 2017; Zheng et al., 2017; Zhang et al., 2018a). This evidence concerns the gene ING5 and thyroid cancer.