However, well-, moderately-, or poorly-differentiated adenocarcinoma was observed in Atp4b-cre; ING5f/f ,pdx1-cre; ING5f/f and K19-cre; ING5f/f mice, even in pdx1-cre; ING5f/f and K19-cre; ING5f/f and wild-type (WT) mice exposed to MNU. This evidence concerns the gene PDX1 and adenocarcinoma.