ING5 and gastric cancer: Qi and Zhang (2014) found that intact ING5 inhibited the proliferation and anti-apoptosis in tongue squamous cell carcinoma cells. In addition, 2 mutants of ING5 (aa 107-226 and 1-184) can facilitate cellular senescence with Cyclin E and CDK2 hypoexpression. In our study, we found that all wild-type and mutant ING5 had either the LZL or PHD domain, and weakened proliferation, migration and invasion of gastric cancer cells, which was closely linked to cdc-2, VEGF, and MMP-9 hypoexpression (Zheng et al., 2022).