The low nuclear expression of ING5 and its nucleocytoplasmic translocation were involved in the tumorigenesis of gastric cancer, breast cancer, HNSCC, and colorectal cancer (Li et al., 2010; Xing et al., 2011; Zheng et al., 2011; Ding et al., 2017). Here, ING5 is linked to head and neck squamous cell carcinoma.