Hypoxia and tumor angiogenic factors, such as Vascular Endothelial Growth Factor (VEGF) can activate and transform quiescent ECs into proliferative stalk cells, this event propagates signaling that results in EndMT, produce de novo fibroblast and myofibroblast activation, extracellular matrix (ECM) deposition, and tissue fibrosis (Bischoff, 2019; Chen et al., 2019; Yao et al., 2019; Eapen et al., 2020; Rossato et al., 2020). The gene discussed is VEGFA; the disease is neoplasm.