The results implied the potential mechanisms between alcohol consumption and DM incidence, the chronic heavy alcohol consumption may induce alteration in glucose levels, insulin resistance, changes in lipid levels and interference in cell signaling (24–26), and individuals with DM who drink heavily were also more likely to have poor self-management behaviors, such as irregular diet, and seldom exercise, compared to those who drink less (27). This evidence concerns the gene INS and diabetes mellitus.