GSE35642 database revealed that FBOX22 is upregulated in an animal model of Parkinson’s disease (PD) via the mechanism of promoting the ubiquitination-dependent degradation of PHLPP1 to ameliorate neurotoxicity, revealing the role of FBXO22 in PD occurrence and progression (Zheng et al., 2021). The gene discussed is PHLPP1; the disease is Parkinson disease.