Adults with solely childhood-onset IgE-FA also reported significantly higher rates of current EAI prescriptions (28.2% vs 18.1%, P < .001), 1 or more lifetime ED visits (44.9% vs 23.1%, P < .001), and 1 or more allergy-related ED visits in the past year (9.5% vs 4.9%, P < .001) compared to adults with adult-onset IgE-FA. The gene discussed is IGHE; the disease is Allergy.