EIF2AK3 and heart failure: A body of work from the Dudley laboratory has demonstrated that under ER stress, the PERK branch of the UPR contributes to the downregulation of other cardiac ion channels in a variety of settings, including human heart failure and in human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) treated with UPR activator tunicamycin (Liu and Dudley, 2014; Liu et al., 2021).