The serine-threonine protein phosphatase calcineurin (PP2B), a focal regulator of cardiac hypertrophy in cardiovascular disease (Wilkins and Molkentin, 2004), is also established as a modulator of RyR2 and SERCA2a function (Bandyopadhyay et al., 2000; Münch et al., 2002). This evidence concerns the gene RYR2 and cardiovascular disorder.