Moreover, HLF could significantly reduce the levels of NLRP3, caspase-1, IL-1β, IL-6, IL-18, and TNF-α and increase the activities of plasma SOD, CAT, and GSH-PX, which suggested that HLF could effectively relieve the inflammatory response and oxidative stress induced by hyperlipidemia. The gene discussed is TNF; the disease is hyperlipidemia.