Taken together the KEGG analysis and the degree values, we supposed that the targets of HLF against hyperlipidemia might be related to the biosynthesis, transport, and homeostasis regulation system of several lipids, including cholesterol, steroids, and fatty acids, and the targets were mainly enriched in APOE, LDLR, PPARG, and so on. Here, APOE is linked to hyperlipidemia.