MAPT and tauopathy: These observations are substantiated by reports suggesting that Hsc70-4 (HSPA8) is involved in aggravating the disease pathogenicity, as observed in tauopathies, where degradation of tau has been reduced by HSPA8 and decrement in this chaperonin level reduces the tau protein (Jinwal et al., 2009, 2013; Fontaine et al., 2015).