Non KEGG pathway was significantly enriched for the parental genes of the DE circRNAs (Figure 7D), the three most enriched KEGG pathways were apoptosis (oas04210), epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor resistance (oas01521), and colorectal cancer (oas05210). The gene discussed is EGFR; the disease is colorectal cancer.