The TNFAIP1/POLDIP2 CSAGA is a clinically relevant transcriptional structural-functional gene module linked to erb-b2 receptor tyrosine kinase 2 (ERBB2) amplicon core gene expression in breast cancer and connected with amplification of the genomic region on 17q11.2. The gene discussed is TNFAIP1; the disease is breast carcinoma.