Experiments have shown that POLDIP3 knockdown in primary leukemia CFU-GM progenitor cells from patients with chronic myeloid leukemia (CML)–or in primary malignant early erythrocyte progenitor cells (BFU-E) from patients with polycythemia vera–have reduced IFN-α-induced inhibitory effects on colony formation. The gene discussed is POLDIP3; the disease is leukemia.