Less commonly, rare genetic syndromes are associated with RCC including von Hippel-Lindau syndrome, Hereditary papillary renal carcinoma, Birt-Hogg-Dube syndrome, Succinate dehydrogenase (SDH)–deficiency, Hereditary leiomyomatosis and renal cell cancer and Hereditary renal carcinoma (HRC). This evidence concerns the gene SDHB and renal cell carcinoma.