AKT1 and keloid: Yan et al. (29) showed that ionizing radiation can inhibit autophagy and promote apoptosis in keloid cells by reducing the expression level of miR-21-5p, and miR-21-5p can regulate this process through the human chromosome 10 deletion phosphatase and tensin homolog (PTEN) and phosphorylated protein kinase B (p-AKT) signaling pathways, thereby preventing local invasion and recurrence of keloids.