IL6 and rheumatoid arthritis: As for clinical-laboratory parameters, patients with RA whose was a high inflammatory activity that of other patients more frequently had high ACPA titers (p = 0.002), poorer physical function according to the HAQ (p = 0.004), and higher levels of ESR (p = 0.019), CRP (p = 0.027), and IL-6 (p = 0.046), as well as lower hemoglobin values (p = 0.021).