A recent study has reported that FSIP2 mutant sperm show a globozoospermia phenotype in addition to flagella defects, and FSIP2 localizes in the acrosome and interacts with proteins associated with acrosome formation, indicating the potential function of FSIP2 in acrosome development (Zheng et al., 2022), which is consistent with single-cell RNA-seq data (Fang et al., 2021). The gene discussed is FSIP2; the disease is Globozoospermia.