Moreover, the interaction between miR-101-3p and PTGS2 has also been demonstrated in colon cancer, gastric cancer and esophageal squamous cell carcinoma but not in bone remodeling (Strillacci et al., 2009; Wang et al., 2010; Gong et al., 2016). This evidence concerns the gene PTGS2 and esophageal squamous cell carcinoma.