Accelerating glycogen metabolism can play a role in suppressing tumors, several enzymes involved in glycogen metabolism exert tumor-suppressive effects, including the glycogen debranching enzyme AGL and the kinase PhK β-subunit (PHKB) (Guin et al., 2016; Richmond et al., 2018; Yang et al., 2019; Liu et al., 2021). This evidence concerns the gene PHKB and neoplasm.