The log2FC of ESCC genomic insertion or deletion mutant genes [CUL3, ZNF750, KDM6A, NFE2L2, and SLC35E2 (Song et al., 2014; Liu et al., 2016; Sawada et al., 2016; Cancer Genome Atlas Research Network et al., 2017)] decreased gradually from Subtype 1 to Subtype 3 (Figure 2C). Here, CUL3 is linked to esophageal squamous cell carcinoma.