TSO/TSOE was also used to diagnose a 72-year-old woman who had had ascending colon adenocarcinoma at the age of 64 and with a family history of muscle disease; a known familial CHEK2 variant NM_007194.3(CHEK2):c.319+2T>A p.? This evidence concerns the gene CHEK2 and colon adenocarcinoma.