Based on the characteristics of gold NPs (AuNPs), which are easily internalized by cells and tissues, Md Imam Uddin et al. constructed antisense sequence (AS)-vascular cell adhesion molecule (VCAM)-1 hAuNPs, which contained antisense sequences complementary to VCAM-1 mRNA, to aggregate to AMD-induced neovascularization. Here, VCAM1 is linked to age-related macular degeneration.