As expected, our findings revealed that WEA administration at all three dosages exhibited antioxidant effects by decreasing hepatic MDA levels, increasing GSH concentration, and increasing SOD activity in the livers of rats with NAFLD, implying that the antioxidant activity of WEA might be attributable to the reduction in lipid peroxidation and augmentation of the endogenous antioxidant activity of the liver. This evidence concerns the gene SOD1 and metabolic dysfunction-associated steatotic liver disease.