PIK3CA and adenocarcinoma: LtfCre0/+; (Gt)R26Pik3ca*H1047R; Trp53fl/fl mice (henceforth, PIK3CA/TP53 mutant mice) develop features of non-invasive hyperplasia, adenocarcinoma, and endometrial intraepithelial carcinoma (the precursor of serous endometrial carcinoma) [31].