This pathway can induce tumor cell apoptosis and includes 57 gene members, such as the tumor suppressors RB1 and PIK3R1, the proto-oncogenes MYC and JUN, as well as transcription factors CITED2 and PPARA. The stimulation of the PPARA pathway increases the volume and number of peroxisomes which are responsible for, among other things, lipid metabolism and catabolism. The gene discussed is PPARA; the disease is neoplasm.