AKT1 and breast cancer: Celastrol is a compound derived from Tripterygium wilfordii root and was reported to inhibit breast cancer cell invasion by reducing NF-ĸB-mediated matrix metalloproteinase-9 expression [39] and also showed anticancer effects on human TNBC, potentially by affecting oxidative stress, apoptosis and the PI3K/Akt pathways [40].