CREB1 and leukemia: Next, we performed molecular phenotype analysis using MsigDB64 (Methods), which revealed that 10q-Del cells exhibit increased activity in several leukemia-relevant signaling pathways, including Wnt, c-Met (a pathway promoted by Wnt signaling65), B cell receptor (BCR) signaling, phosphatidylinositol (3,4,5)-trisphosphate (PIP3) signaling and the CREB pathway (10% FDR; Fig. 4d).