The superior frontal gyrus (SFG) at the level of the frontal eye fields and the insular cortex were chosen as regions of interests because of the higher severity of tau aggregation seen in these regions across the clinical spectrum of primary tauopathies ranging from behavioral variant frontotemporal dementia (bvFTD) to Richardson’s syndrome21. The gene discussed is MAPT; the disease is behavioral variant of frontotemporal dementia.