Brain MTBR-tau282/t-tau had a similar increase profile to MTBR-tau275/t-tau (Fig. 1c) but moderately (2.6-fold) increased in AD (0.915 ± 0.180) compared to FTLD-TDP (0.348 ± 0.133, P < 0.05), which was not observed in MTBR-tau275/t-tau. Here, MAPT is linked to Alzheimer disease.