When S7-A cells were infected with HCV-JFH1-tau Lot B1 with or without a broad CLDN binder, i.e., C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE), which can bind several CLDNs such as CLDN3, CLDN6, CLDN7, and CLDN917,18, infection was completely blocked by C-CPE (Supplementary Fig. S7). Here, CLDN6 is linked to infection.