The AlphaFold predictions of the same proteins (AF-P22413, AF-Q13822, AF-O14638, AF-Q9Y6X5, AF-Q9UJA9, AF-Q6UWR7, AF-Q6UWV6 for ENPP1-7, respectively) show more divergence, especially histidine R5 (Fig. 4d). The gene discussed is ENPP1; the disease is atrial fibrillation.