The dark-green cluster (AML-mono) was enriched in progenitor cell markers of the monocytic lineage such as Ctss, Cnn3, Ms4a6c, Pira2 and Lsp1 (refs. 3,26,33), as well as Itgb7 and Flt3 (Fig. 4i, Extended Data Fig. 8f and Supplementary Table 2), which have been associated with stronger leukemia-initiating capacity in Hoxa9/Meis1 AML34. This evidence concerns the gene CTSS and acute myeloid leukemia.