We also observed a significant increase in the number of colocalisation between Tomm20 and LC3B in all SNCA-PD lines compared to control lines (Fig. 6n) (Ctrl = 176 ± 26, SNCA PD = 292 ± 45, P < 0.05), as well as more LC3B puncta per cell (Fig. 6o and Supplementary Fig. 8j, k) (Ctrl = 385 ± 62, SNCA PD = 679 ± 98, P < 0.05), suggesting close contact between autophagosomes and the mitochondria and an autophagosome response. Here, TOMM20 is linked to Parkinson disease.