CDA and cancer: To support these observations, we studied the CDA gene expression in cell lines from the Cancer Cell Line Encyclopedia 21q4 (CCLE) database available in R2 (http://r2.amc.nl) and found a significantly lower expression of CDA (FDR < 0.01) in some pediatric cancers including neuroblastoma (two-sided Welch’s T-test, FDR <1 × 10−35, Table S1).