YY1 and acute myeloid leukemia: To determine whether YY1 enhances AML cell proliferation by increasing METTL3 expression, we further transfected YY1-overexpressing THP-1 and Kasumi-1 cells with METTL3-interfering lentivirus and performed western blotting to detect YY1 and METTL3 expression in THP-1 and Kasumi-1 cells (Fig. 2A, B).