Previous study has shown that CD147 promotes M1 macrophage polarization, which induces differentiation of Th17 cells and the progression of lung interstitial fibrosis.48 The impact of CD147 in SARS-CoV-2-induced pulmonary fibrosis may be not only due to its contribution to virus entry and immune responses, but also due to its role as a crucial regulator for fibroblasts activation. This evidence concerns the gene BSG and pulmonary fibrosis.