The destruction of insulin‐secreting β‐cells by islet specific autoreactive T cells is major pathogenesis of type 1 diabetes.[54] In a mouse model of type 1 diabetes, PD‐L1‐engineered platelets could actively target inflammatory pancreatic tissues, which would interact with T cells and inhibit the activity of autoreactive T cells in the pancreas, thereby maintaining the integrality of insulin‐secreting β‐cells. Here, INS is linked to type 1 diabetes mellitus.