When the list of proteins is sorted by SD value in ascending order, TPD52L2, EIF4B, CD63, MCEE, VAPA, LUC7L2, PCNP, MT1F, NIPBL, SERF2, SDC4, and so on were the most upregulated proteins in PD, whereas MRPL28, hCG_1984214, MRPL37, MRPS9, RTL8C, MRPS24, TIMM23B, MRPL3, MRPL38, LNPEP, and so on were the most downregulated proteins in PD. The gene discussed is SDC4; the disease is Parkinson disease.