PRKN and Parkinson disease: The implication of aberrant alternative splicing of PD-related proteins in the PD pathogenesis has been reported; alternative splicing of SNCA can accelerate or decelerate the aggregation of α-synuclein, several pathogenic mutations affect LRRK2 alternative splicing, and alternative spliced PARK2 (Parkin) variants are implicated in juvenile Parkinsonism (78, 79, 80).