When overexpressed, miniSOX9 inhibited SOX9-driven reporter activity and also alleviated SOX9’s inhibition of Wnt readouts, leading to a model of miniSOX9 as a naturally occurring dominant negative variant that allowed the SOX9 gene to stimulate cancer growth by inhibiting the ability of full-length SOX9 to repress Wnt signaling (61). Here, SOX9 is linked to cancer.