Besides expressing SPP1, we found that SPP1+ TAM also expressed APOC4-APOC2, a gene not reported by previous RCC studies (Figure S5C), and TREM2 (Figure 5C), which has been reported in various biological and pathological processes such as obesity and cancer.40 The gene discussed is APOC2; the disease is obesity due to melanocortin 4 receptor deficiency.