While the evidence linking ERBB4 with intellectual disability and ASD is scarce (58, 59), the enrichment of autism-associated genes among the genes downregulated in ErbB4 conditional mutants and the identification of NLGN3 as a target of ErbB4-Tsc2 signaling in the formation of excitatory synapses onto PV+ interneurons is intriguing because mutations in TSC2 and NLGN3 are associated with ASD (60–64). This evidence concerns the gene TSC2 and autism.