Importantly, treatment of TR3, TR5, H3122, or H2228 cells with EGF elicited increased resistance to ALK inhibition, while the combined inhibition of ALK and PI3Kβ rescued the EGF‐induced resistance, together suggesting that inhibition of PI3Kβ restricts EGFR‐mediated bypass resistance to ALK inhibition in ALK‐rearranged lung cancer (Fig. 5C and Fig. S10). This evidence concerns the gene EGF and lung cancer.