In contrast to these influenza-susceptible alleles, different studies have shown that HLA-A*01:01, HLA-A*02:01, HLA-A*03:01, HLA-B*08:01, HLA-B*18:01, HLA-B*27:05, HLA-B*37:01, and HLA-B*57:01 present highly conserved influenza viral peptides and were associated with universal protective CD8+ T cell-mediated immunity [59,115,144]. This evidence concerns the gene HLA-B and influenza.