The HCC patients in Vietnam were younger (p < 0.001), and had significantly higher serum AFP level (p < 0.001), larger size of tumor (p < 0.001) and tended to have a single tumor (p < 0.001), having macrovascular invasion (p < 0.001) and extrahepatic metastasis (p < 0.001), compared to those in Taiwan. Here, AFP is linked to hepatocellular carcinoma.