In this cohort of Chinese COVID-19 patients, we did not observe a statistically significant difference in the frequency of the CC genotype between the mild, severe, and fatal COVID-19 cases, nor the viral loads, but did find significantly higher presentations of the CC genotype in SARS-CoV-2 positive individuals, suggesting an association of IFITM3 with the acquisition of SARS-CoV-2 infection. Here, IFITM3 is linked to COVID-19.