LDLRAD3 is expressed in various tissues, including the brain, respiratory system, GI tract, reproductive tracts, and connective and soft tissues; its expression is abundant in myeloid cells [109] LDLRAD3 promotes the activity of E3 ubiquitin ligases [110] and serves a receptor for Venezuelan equine encephalitis virus, a neurotropic alphavirus transmitted by mosquitoes that causes encephalitis and death in humans [88]. This evidence concerns the gene LDLRAD3 and encephalitis.